Small molecules.
Enormous potential.

Our Pipeline

The cancers we’re targeting
make up nearly

72%

of all inpatient
oncology procedures

Ovarian
Lung
Prostate
Colorectal

Our portfolio has the
potential to impact

3 million

procedures annually, across a
variety of surgical approaches

Open
Minimally Invasive
Robotic
Interventional

Our Science

On Target is the first to utilize small molecule technology to target unique characteristics of cancer cells, providing a clear differentiation between healthy and malignant tissue in the operating room. The benefit of small molecules is that they move through the body quickly. This quick action allows for flexible dosing schedules prior to surgery and minimal impact to workflow in the operating room.

Once our molecules reach their target they are endocytosed and remain inside the cancer cells throughout the length of the procedure.

Each small molecule is attached to a fluorescent dye that “lights up” malignant lesions via a near-infrared imaging system.

Because the imaging system, coupled with our bright dye, operates in the near-infrared spectrum, it optimizes visibility – even in lesions that are below the tissue surface.

Featured Publications

April 24, 2026
The Role of Intraoperative Imaging Technique for Ground Glass Opacities (GGOs) During Video-Assisted Thoracic Surgery (VATS): Findings From an Integrated Health System
Read More
June 1, 2025
Real-world localization of cancer in lungs with a commercially available folate receptor-targeted fluorescent agent for intraoperative molecular imaging
Read More
December 18, 2024
Intraoperative Molecular Imaging With Pafolacianine: Histologic Characteristics of Identified Nodules
Read More
October 1, 2024
Intraoperative Molecular Imaging With Pafolacianine in Resection of Occult Pulmonary Malignancy in the ELUCIDATE Trial
Read More
March 3, 2023
Lung Cancer Phase 3 Study (ELUCIDATE)
Read More
November 19, 2020
Multi-Institutional Phase 2 Clinical Trial of Intraoperative Molecular Imaging of Lung Cancer
Annals of Thoracic Surgery
Read More
October 10, 2019
A phase II, multicenter, open-label trial of OTL38 injection for the intra- operative imaging of folate receptor-alpha positive ovarian cancer
Gynecologic Oncology
Read More
July 13, 2018
Localization of Pulmonary Ground-Glass Opacities with Folate Receptor–Targeted Intraoperative Molecular Imaging
Journal of Thoracic Oncology
Read More
March 10, 2018
A Phase I Clinical Trial of Targeted Intraoperative Molecular Imaging for Pulmonary Adenocarcinomas
The Annals of Thoracic Surgery
Read More
February 5, 2018
An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas
Oncotarget
Read More
September 26, 2017
Intraoperative Molecular Imaging Combined With Positron Emission Tomography Improves Surgical Management of Peripheral Malignant Pulmonary Nodules
Annals of Surgery
Read More
June 15, 2016
A Novel Tumor-Specific Agent for Intraoperative Near-Infrared Fluorescence Imaging: A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer
Clinical Cancer Research
Read More
September 18, 2011
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
Nature Medicine
Read More
Brand Strategy By Assembly
Developed By Alchemy + Aim