Small molecules.
Our Pipeline
The cancers we’re targeting
make up nearly
72%
of all inpatient
oncology procedures
Ovarian
Lung
Prostate
Colorectal
Our portfolio has the
potential to impact
3 million
procedures annually, across a
variety of surgical approaches
Open
Minimally Invasive
Robotic
Interventional
Our Science
On Target Laboratories is the first to utilize small molecule technology to target unique characteristics of cancer cells, providing a clear differentiation between healthy and malignant tissue in the operating room. The benefit of small molecules is that they move through the body quickly. This quick action allows for flexible dosing schedules prior to surgery and minimal impact to workflow in the operating room.
Once our molecules reach their target they are endocytosed and remain inside the cancer cells throughout the length of the procedure.
Each small molecule is attached to a fluorescent dye that “lights up” malignant lesions via a near-infrared imaging system.
Because the imaging system, coupled with our bright dye, operates in the near-infrared spectrum, it optimizes visibility – even in lesions that are below the tissue surface.
Featured Publications
Lung Cancer Phase 3 Study (ELUCIDATE) Multi-Institutional Phase 2 Clinical Trial of Intraoperative Molecular Imaging of Lung Cancer Annals of Thoracic Surgery, November 2020 A phase II, multicenter, open-label trial of OTL38 injection for the intra- operative imaging of folate receptor-alpha positive ovarian cancer Gynecologic Oncology, October 2019 Localization of Pulmonary Ground-Glass Opacities with Folate Receptor–Targeted Intraoperative Molecular Imaging Journal of Thoracic Oncology, July 2018 A Phase I Clinical Trial of Targeted Intraoperative Molecular Imaging for Pulmonary Adenocarcinomas The Annals of Thoracic Surgery, March 2018 An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas Oncotarget, February 2018 Intraoperative Molecular Imaging Combined With Positron Emission Tomography Improves Surgical Management of Peripheral Malignant Pulmonary Nodules Annals of Surgery, September 2017 A Novel Tumor-Specific Agent for Intraoperative Near-Infrared Fluorescence Imaging: A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer Clinical Cancer Research, June 2016 Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results Nature Medicine, September 2011Archive
Evaluation of Novel Prostate-Specific Membrane Antigen-Targeted Near-Infrared Imaging Agent for Fluorescence-Guided Surgery for Prostate Cancer Comparison of Folate Receptor Targeted Optical Contrast Agents for Intraoperative Molecular Imaging Intraoperative Molecular Imaging of Lung Adenocarcinoma Can Identify Residual Tumor Cells at the Surgical Margins Tumor-Specific Agent for Intraoperative Near-Infrared Fluorescence Imaging: A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer Folate receptor-α targeted near-infrared fluorescence imaging in high-risk endometrial cancer patients: a tissue microarray and clinical feasibility study Intraoperative molecular imaging can identify subcentimeter peritoneal implants during ovarian cancer cytoreductive surgery Development of tumor-targeted near infrared probes for fluorescence guided surgery
Brand Strategy By
Assembly
Developed By
Alchemy + Aim